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New England Complex Systems Institute
238 Main Street Suite 319, Cambridge, MA 02142
Phone: 617-547-4100 Fax: 617-661-7711

NECSI research applies complex systems concepts to describe how cell behavior arises from molecular components. Our theoretical and experimental studies based on high throughput data have resulted in models that accurately represent the behavior of an entire cell, and can predict cell response to stimuli.

Publications, Books & Edited Volumes

Y. Bar-Yam, D. Harmon, B. L. de Bivort. Attractors and democratic dynamics, Science 323, 1016-1017 (2009). full article press release

B. de Bivort, S. Huang, Y. Bar-Yam. Empirical multiscale networks of cellular regulation, PLoS Computational Biology 3, e207 (2007). full article

B. L. de Bivort, C.-C. Chen, F. Perretti, G. Negrob, T. M. Philip, Y. Bar-Yam. Metabolic implications for the mechanism of mitochondrial endosymbiosis and human hereditary disorders, Journal of Theoretical Biology 248, 26-36 (2007). summary press release PDF file

S. Huang, G. Eichler, Y. Bar-Yam, D. E. Ingber, Cell fates as high-dimensional attractor states of a complex gene-regulatory network, Physical Review Letters 94, 128701 (2005). Abstract PDF file news article

B. de Bivort, S. Huang, Y. Bar-Yam, Dynamics of cellular-level function and regulation derived from Murine expression array data, PNAS 101, 17687-92 (2004). Abstract PDF file press release

Photo © B. L. de Bivort