Mathematical modeling the pathway of human breast cancer
Central China Normal University
Nationa Cancer Institute in NIH
Last modified: June 30, 2007
We put the biological hypotheses into the multistage models that the age dependent dynamics of normal breast tissue, clonal expansion of intermediate cells and mutation rates to fit the age-specific incidence of breast cancers in the surveillance, epidemiology, and end results (SEER) Registry. To our knowledge, this is the first paper that can accept and reject some biological hypotheses by using the statistical inference combined with mathematical modeling of the genetic pathways of cancer. Our results suggest that loss of functions of instability genes is an early event in the tumorigenesis which is useful for early diagnosis of breast cancer, the clonal expansion of intermediate cells must depend on the expression level of hormone of females which indicates that it is effective for hormone therapy to breast cancer for the female before her menopause and mutations in the genome of normal breast stem cells play more important roles than clonal expansions of intermediate cells in the tumorigenesis.