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International Conference on Complex Systems (ICCS2006)

An agent-based model for Leishmania infection

Garrett Dancik
Program in Bioinformatics and Computational Biology, Iowa St

Karin Dorman
Department of Statistics, Genetics, Development and Cell Biology, Iowa State University

Doug Jones
Department of Veterinary Pathology, Iowa State University

Appendix: Agent-based model parameters

Appendix – Agent-based model parameters

Appendix – Agent-based model parameters

 

Class

Param

Description

Range / Value

Unit

Ref

Chemokine

 

 

λ   

Chemokine diffusion coefficient

0.64

/ .1 min

1

γ  

Chemokine degradation coefficient

0.001

/ .1 min

1

CR

Minimum amount of chemokine necessary to influence cell movement

1

scalar

1

Leishmania

αI

Intracellular parasite growth rate

(2.40705-5, 9.6317-5)

/ .1 min

2, e

Macrophages

 

 

 

Mls

Resting, non-inflammatory macrophage lifespan

100

days

1

Mals

Activated macrophage lifespan

(1/3, 4)

days

e

Mils

Inflammatory macrophage lifespan ~ U(2,Mils) days

(3, 11)

days

2,e

KI

Transfer threshold of infected macrophages

(8,35)

scalar

e

Mrsp

Resting macrophage speed

(0.5, 1.5)

μm / min

1

Masp

Activated macrophage speed

(0.0125, 0.5)

μm / min

1

Misp

Infected macrophage speed

0.0007

μm / min

1

Minit

Initial number of macrophages

105

scalar

1,e

initAg

Initial # of parasite

50

scalar

e

Pm

Maximum number of parasite per initially infected macrophage

4

scalar

e

T Cells

 

 

Tdelay

Minimum number of parasites required for T cell response to begin

800, 3000

scalar

e

Tmove

Prob. of T cell movement

(5, 90)

%

e

Tactm

Prob. A T cell will activate a macrophage

(5, 90)

%

e

Tls

T cell lifespan

3

Days

1

Tsp

T cell speed

2

μm / min

1

Recruitment

Mrecr

Prob. of macrophage recruitment

(0.22, 0.52)

% / ts

2,e

Trecr

Prob. of T cell recruitment

(0.0250, 0.2100)

% / ts

2,e

CM

Minimum amount of chemokine needed at source for macrophage recruitment

1

scalar

1

CT

Minimum amount of chemokine needed at source for T cell recruitment

1

scalar

1

 

Miscellaneous

Update

All interactions occur every Update minutes

10

minutes

e

 

Table A.1. ABM parameters. Reference codes: 1. Segovia-Juarez [2004], and references within; 2. Belkaid [2000]; e. estimate.

 

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