Dynamics of behavioral state control in the mouse sleep-wake network

Cecilia Diniz Behn
Neurology, Beth Israel Deaconess Medical Center

Emery Brown
Anesthesia and Critical Care, Massachusetts General Hospital

Thomas Scammell
Neurology, Beth Israel Deaconess Medical Center

Nancy Kopell
Mathematics, Boston University

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     Last modified: June 9, 2006

Abstract
Behavioral states (wake, NREM sleep, and REM sleep) and transitions between them are regulated by a network of neurons in the brainstem and hypothalamus. We model network dynamics with a system of coupled Morris-Lecar-type relaxation oscillators. The fast-slow nature of the equations captures network behavior on multiple time scales. We study mechanisms of transition in reduced models obtained using combinations of fast-slow and dominant scale techniques.